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Literature summary extracted from

  • O'Donnell, C.D.; Tiwari, V.; Oh, M.; Shukla, D.
    A role for heparan sulfate 3-O-sulfotransferase isoform 2 in herpes simplex virus type 1 entry and spread (2006), Virology, 346, 452-459.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.29 3-OST-2, transient expression in CHO-K1 cells Homo sapiens
2.8.2.30 3-OST-3, transient expression in CHO-K1 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.8.2.29 additional information expression of 3-OST-2 renders CHO-K1 cell, which are normally resistant, susceptible to viral entry of wild-type and a Q27P mutant, Rid1, forms of HSV-1, requiring the gD receptors, Rid1 mutation at gD prevents its entry via some receptors including HVEM and 3-OS HS generated by 3-OST-3, overview Homo sapiens
2.8.2.30 additional information expression of 3-OST-3 leads to cell-to-cll fusion activity in CHO-K1 cells via gD receptors modified with 3-OS HS generated by 3-OST-3, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.29 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine Homo sapiens
-
 adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?
2.8.2.29 additional information Homo sapiens modification of heparan sulfate and the ability of 3-OST-2 to generate receptors for both wild-types and some mutant forms of HSV-1, spreading of receptors mediating cell-to-cell fusion ?
-
 ?
2.8.2.30 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine Homo sapiens 3-OST-3 is involved in 3-OST-2-mediated HSV-1 entry into cells by catalyzing the preceeding step of 3-O-sulfated heparin sulfate modification of receptors adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.29 Homo sapiens Q9Y278
-
-
2.8.2.30 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.29 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 Homo sapiens adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?
2.8.2.29 additional information modification of heparan sulfate and the ability of 3-OST-2 to generate receptors for both wild-types and some mutant forms of HSV-1, spreading of receptors mediating cell-to-cell fusion Homo sapiens ?
-
 ?
2.8.2.29 additional information HSV-1 glycoprotein gD, both the wild-type and the mutant Rid1 form, can interact with [heparan sulfate]-glucosamine 3-sulfate generated by HS 3-OST-2, overview Homo sapiens ?
-
 ?
2.8.2.30 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 Homo sapiens adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?
2.8.2.30 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine 3-OST-3 is involved in 3-OST-2-mediated HSV-1 entry into cells by catalyzing the preceeding step of 3-O-sulfated heparin sulfate modification of receptors Homo sapiens adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.29 3-O-sulfotransferase-2
-
 Homo sapiens
2.8.2.29 3-OST-2
-
 Homo sapiens
2.8.2.29 heparan sulfate 3-O-sulfotransferase 2
-
 Homo sapiens
2.8.2.29 HS 3-OST-2
-
 Homo sapiens
2.8.2.30 3-O-sulfotransferase-3
-
 Homo sapiens
2.8.2.30 3-OST-3
-
 Homo sapiens
2.8.2.30 heparan sulfate 3-O-sulfotransferase 3
-
 Homo sapiens
2.8.2.30 HS 3-OST-3
-
 Homo sapiens